A non-human primate model of ALS provides a valuable tool for studying the disease's progression and potential treatments.

A non-human primate model of Amyotrophic Lateral Sclerosis hypothes.is/a/SWIPjj7zEfGMthPv24-nRQ **Reviewer #3 (Public review):** Summary: In this paper by Jones and colleagues, a non-human primate model is described in which wild-type TDP-43 is expressed in the cervical spinal cord. This gave rise to loss of motor neurons in the ventral…

A non-human primate model of Amyotrophic Lateral Sclerosis hypothes.is/a/SZAZJD7zEfGrU7PAMECJWw **Reviewer #2 (Public review):** Summary: There are astonishingly few papers trying to reproduce the process of initiation and spreading that Braaks studies have suggested and postulated. The authors should be applauded for pioneering such a…

A non-human primate model of Amyotrophic Lateral Sclerosis hypothes.is/a/STR0hD7zEfGSpzuXURiXKw **Reviewer #4 (Public review):** Summary: In this manuscript, the authors present data describing the development of a model of ALS in rhesus macaques. They use a viral intersectional model to overexpress TDP-43 in a population of motor neurons…

A non-human primate model of Amyotrophic Lateral Sclerosis hypothes.is/a/Sbo0hD7zEfGpBZPgUMgN4g **Reviewer #1 (Public review):** Summary: The authors have used a macaque (two animals only) to follow the migration of 'seeded' TDP43 protein in neuronal pathways - thus mimicking the spread of ALS in the human CNS. Previous experiments in…