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Action potential broadening is not a universal feature of homeostatic plasticity in response to chronic activity deprivation.

ScienceApr 23, 2026score 0.175 posts · 0 replies across 1 instances
This thread discusses a scientific study examining whether action potential broadening is a reliable mechanism for homeostatic plasticity in cultured neurons. The study addresses previous findings and includes reviews and author responses.

Claims

Action potential broadening is not a universal feature of homeostatic plasticity in response to chronic activity deprivation.
Parent: NeuroscienceEntity: Homeostatic plasticitySub-entity: Action potential broadeningImpact: negativeDate: Apr 23, 2026Target: The reliability of action potential broadening as a homeostatic mechanism

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Unreliable homeostatic action potential broadening in cultured dissociated neurons hypothes.is/a/xdj2lD8rEfGChPdoIhPHzA **Reviewer #1 (Public review):** \[Editors' note: The Reviewing Editor has assessed the revised manuscript without seeking further input from the original reviewers. The authors have addressed the main points raised during peer review, including…
0 boosts · 0 favs · 0 replies · Apr 23, 2026
@[email protected]
Unreliable homeostatic action potential broadening in cultured dissociated neurons hypothes.is/a/xgjzYj8rEfGktGOyzBPdBw **eLife Assessment** This study provides compelling evidence that action potential (AP) broadening is not a universal feature of homeostatic plasticity in response to chronic activity deprivation. By leveraging state-of-the-art methods across multiple…
0 boosts · 0 favs · 0 replies · Apr 23, 2026
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Unreliable homeostatic action potential broadening in cultured dissociated neurons hypothes.is/a/xabN9D8rEfGDUGeeFkYxxA **Reviewer #2 (Public review):** Summary: This study reexamined the idea that action potential broadening serves as a homeostatic mechanism to compensate for changes in network activity. The key finding was that, while action potential broadening…
0 boosts · 0 favs · 0 replies · Apr 23, 2026
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Unreliable homeostatic action potential broadening in cultured dissociated neurons hypothes.is/a/xXbJ2D8rEfGB4I8kx3eSew **Reviewer #3 (Public review):** Summary: The manuscript "Unreliable homeostatic action potential broadening in cultured dissociated neurons" by Ritzau-Jost et al. investigates action potential (AP) broadening as a mechanism underlying…
0 boosts · 0 favs · 0 replies · Apr 23, 2026
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Unreliable homeostatic action potential broadening in cultured dissociated neurons hypothes.is/a/xUd2TD8rEfGEyBPOj80mWA **Author response:** The following is the authors’ response to the original reviews. > **Public Reviews:** > > **Reviewer #1 (Public review):** > > Summary: > > Ritzau-Jost et al. investigate the potential contribution of AP broadening in homeostatic…
0 boosts · 0 favs · 0 replies · Apr 23, 2026
@[email protected]
Unreliable homeostatic action potential broadening in cultured dissociated neurons hypothes.is/a/xgjzYj8rEfGktGOyzBPdBw **eLife Assessment** This study provides compelling evidence that action potential (AP) broadening is not a universal feature of homeostatic plasticity in response to chronic activity deprivation. By leveraging state-of-the-art methods across multiple…
0 boosts · 0 favs · 0 replies · Apr 23, 2026
@[email protected]
Unreliable homeostatic action potential broadening in cultured dissociated neurons hypothes.is/a/xdj2lD8rEfGChPdoIhPHzA **Reviewer #1 (Public review):** \[Editors' note: The Reviewing Editor has assessed the revised manuscript without seeking further input from the original reviewers. The authors have addressed the main points raised during peer review, including…
0 boosts · 0 favs · 0 replies · Apr 23, 2026