ARHGAP36 is a direct transcriptional target of FOXC1 that regulates Hedgehog signaling in neuroblastoma.

Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival hypothes.is/a/-2CnKDzMEfG-ocP3wJdmUQ **Reviewer #1 (Public review):** This thoughtful and thorough mechanistic and functional study reports ARHGAP36 as a direct transcriptional target of FOXC1 which regulates Hedgehog signaling (SUFU, SMO, and GLI family transcription factors) through…

Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival hypothes.is/a/-y32ejzMEfGjO2sxa4kvoQ **Reviewer #2 (Public review):** FOXC1 is a transcription factor essential for the development of neural crest-derived tissues and has been identified as a key biomarker in various cancers. However, the molecular mechanisms underlying its function…

Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival hypothes.is/a/-48G9DzMEfGhi5ctWd6c2w **eLife Assessment** This important study examines the potential role of ARHGAP36 transcriptional regulation by FOXC1 in controlling sonic hedgehog signaling in human neuroblastoma. While there are many solid findings that strongly support this…

Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival hypothes.is/a/-r2qCjzMEfGD3IcZLp6deQ **Author response:** The following is the authors’ response to the original reviews. > **Public Reviews:** > > **Reviewer #1 (Public review):** > > This thoughtful and thorough mechanistic and functional study reports ARHGAP36 as a direct…