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DEER spectroscopy can effectively evaluate the supramolecular packing of amyloid fibrils formed by misfolded proteins.

Neurodegenerative DiseasesTechnologyHealthcareScienceApr 20, 2026score 0.172 posts · 0 replies across 1 instances
The thread discusses the use of DEER (Double Electron-Electron Resonance) spectroscopy to study the structural variations in Tau fibrils, which are associated with different neurodegenerative pathologies. The focus is on understanding supramolecular packing in amyloid fibrils through singly labelled proteins.

Claims

DEER spectroscopy can effectively evaluate the supramolecular packing of amyloid fibrils formed by misfolded proteins.
Parent: Medical ResearchEntity: DEER spectroscopyImpact: positiveDate: Apr 20, 2026Target: DEER spectroscopy's effectiveness in evaluating supramolecular packing of amyloid fibrils

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DEER of Singly Labelled Proteins to Evaluate Supramolecular Packing of Amyloid Fibrils hypothes.is/a/G1fX4DyMEfGWqT_NaVb_Bw **Reviewer #1 (Public review):** Summary: Proteins' misfolding into amyloid fibrils is the hallmark of neurodegenerative disorders. Tau fibrils, in particular, exhibit subtle structural variations that distinguish different pathologies.…
0 boosts · 0 favs · 0 replies · Apr 20, 2026
@[email protected]
DEER of Singly Labelled Proteins to Evaluate Supramolecular Packing of Amyloid Fibrils hypothes.is/a/G1fX4DyMEfGWqT_NaVb_Bw **Reviewer #1 (Public review):** Summary: Proteins' misfolding into amyloid fibrils is the hallmark of neurodegenerative disorders. Tau fibrils, in particular, exhibit subtle structural variations that distinguish different pathologies.…
0 boosts · 0 favs · 0 replies · Apr 20, 2026