Erythromycin and its derivatives can improve muscle endurance by regulating orosomucoid, a protein associated with anti-fatigue effects.

Erythromycin has therapeutic efficacy on muscle fatigue acting specifically on orosomucoid to increase muscle bioenergetics and physiological parameters of endurance [2020] abstract: https://pubmed.ncbi.nlm.nih.gov/32777256/ preprint can be downloaded here: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3463265 #orosomucoid #fatigue #erythromycin #DrugRepurposing #DrugDevelopment

A non-antibiotic erythromycin derivative improves muscle endurance by regulating endogenous anti-fatigue protein orosomucoid in mice [2024] abstract: https://pubmed.ncbi.nlm.nih.gov/38815994/ preprint download: https://www.researchgate.net/publication/374021571_A_non-antibiotic_erythromycin_derivative_improves_muscle_endurance_by_regulating_endogenous_anti-fatigue_protein_orosomucoid/fulltext/65099cb1d5293c106cc89292/A-non-antibiotic-erythromycin-derivative-improves-muscle-endurance-by-regulating-endogenous-anti-fatigue-protein-orosomucoid.pdf #orosomucoid #fatigue #erythromycin #DrugDevelopment