GM-CSF plays a regulatory role in preventing the loss of ILC3 populations and inhibiting pro-inflammatory cytokine production during gut inflammation in Crohn’s disease.

GM-CSF regulates ILC states and myeloid cell signaling during ulceration in Crohn’s disease hypothes.is/a/QE-XyD40EfGsfXc-pUdRyA **Reviewer #2 (Public review):** The authors show that GM-CSF prevents the loss of ILC3 populations and inhibits pro-inflammatory cytokine production during gut inflammation. They combine a preclinical model of gut inflammation in zebrafish with…

GM-CSF regulates ILC states and myeloid cell signaling during ulceration in Crohn’s disease hypothes.is/a/QKuTUj40EfGMa0dH3sdqSQ **eLife Assessment** The authors provide valuable findings showing that GM-CSF prevents the loss of ILC3 populations during gut inflammation and inhibits pro-inflammatory cytokine production. They combine a preclinical model of gut inflammation in…

GM-CSF regulates ILC states and myeloid cell signaling during ulceration in Crohn’s disease hypothes.is/a/QHmCkD40EfGvnE84M-mdLg **Reviewer #1 (Public review):** This study integrates Xenium spatial transcriptomics of paired inflamed and uninvolved Crohn's disease tissues with functional analyses in a csf2rb-/- larval zebrafish DSS intestinal injury model to investigate the…

GM-CSF regulates ILC states and myeloid cell signaling during ulceration in Crohn’s disease hypothes.is/a/QBfdsD40EfGjF4Oib1ykfw **Author response:** We thank the editors and reviewers for their careful evaluation of our manuscript, “GM-CSF regulates ILC states and myeloid cell signaling during ulceration in Crohn’s disease.” We appreciate the constructive feedback and agree that…