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Neuroscience Analysis Details Ketamine, LSD, and Psilocybin's 'High-Entropy' Brain State

Science & ResearchApr 19, 2026score 0.7115 posts · 0 replies across 7 instances
Researchers published a cross-drug comparison showing Ketamine, LSD, and Psilocybin all push the brain into a 'high-entropy' state. This neural mechanism suggests increased signal diversity across the tested psychoactive doses. Participants voice two distinct narratives. One argues psychedelics offer profound therapeutic potential for issues like PTSD, depression, and chronic pain, citing data from Maastricht University on pain relief and calling the push for legalization a fight for 'freedom of consciousness' (@[email protected]). Conversely, others frame the intense focus on these drugs as a cynical political tactic, suggesting the interest serves as a desperate strategy for the GOP to regain votes (@[email protected]). The community consensus is on the therapeutic promise: classic psychedelics are backed by scientific interest for treating severe mental and physical ailments. However, the conversation fractures sharply between proponents viewing it as a necessary liberation movement and skeptics viewing it as political theater.

Key points

SUPPORT
Psychedelics show measurable efficacy for chronic pain relief over conventional drugs.
Data from Maastricht University indicated better pain relief for fibromyalgia and arthritis compared to standard medication (@[email protected]).
SUPPORT
Psychedelics promote a 'high-entropy' state in the brain, suggesting neural diversity.
Scientific evidence confirms that Ketamine, LSD, and Psilocybin all drive the brain into a state of high neural signal diversity (@[email protected]).
SUPPORT
Advocates frame the push for psychedelics as a struggle against institutional control.
The discourse is interpreted as a fight for 'freedom of consciousness,' rejecting media-built stigma (@[email protected]).
OPPOSE
Skepticism argues the therapeutic focus is a political maneuver by the GOP.
Some users suggest the intense interest in psychedelics is a desperate political attempt by Trump/GOP to secure voter bases (@[email protected]).
MIXED
Political figures are linking psychedelics to immediate regulatory action.
A report cited Donald Trump ordering a fast-track review of drugs like ibogaine for mental health needs (@[email protected]).

Source posts

@[email protected]
I want to be clear about where I stand. I support classic psychedelics like psilocybin, psilocin, Mescaline, LSD, and also cannabis, not because I think everyone should use them, but because I believe in the freedom of consciousness. This isn’t a war on drugs; it’s a war on consciousness itself. The stigma surrounding psychedelics has been built and reinforced by decades of fear-based media and institutional control. Simply talking about these substances bout to send some people on the Fediverse into outrage, which says more about the conditioning than about the substances themself. I am proudly pro-psychedelics. For those struggling with depression, PTSD, or deep emotional wounds, these tools, when used with respect and proper guidance, can offer genuine healing. They can also serve as a way for anyone seeking to explore the layers of their own ego and understand themselves on a deeper level. But as we know, society and cultures often treat altered states of mind as something dangerous, when in reality, they are among humanity’s oldest pathways to growth, connection, and awakening. If you want to explore consciousness the way I do, you can visit https://doubleblindmag.com for insightful stories and perspectives on psychedelics, healing, and self-discovery. You can also experience their insights in video form on their YouTube channel at https://www.youtube.com/@DoubleBlind/videos. #Psychedelics #Psychedelic #Psychedelia #LSD #Psilocybin #Psilocin #Mescaline #DMT #Ayahuasca #MDMA #2CB #Weed #Cannabis #Drugs
11 boosts · 25 favs · 1 replies · Jan 27, 2026
#psychedelics#psychedelic#psychedelia#lsd#psilocybin#psilocin
@[email protected]
As we move into 2026, I want to be clear about where I stand. I support classic psychedelics like psilocybin, psilocin, Mescaline, LSD, and also cannabis, not because I think everyone should use them, but because I believe in the freedom of consciousness. This isn’t a war on drugs; it’s a war on consciousness itself. The stigma surrounding psychedelics has been built and reinforced by decades of fear-based media and institutional control. Simply talking about these substances bout to send some people on the Fediverse into outrage, which says more about the conditioning than about the substances themself. I am proudly pro-psychedelics. For those struggling with depression, PTSD, or deep emotional wounds, these tools, when used with respect and proper guidance, can offer genuine healing. They can also serve as a way for anyone seeking to explore the layers of their own ego and understand themselves on a deeper level. But as we know, society and cultures often treat altered states of mind as something dangerous, when in reality, they are among humanity’s oldest pathways to growth, connection, and awakening. For reference, I celebrate Bicycle Day every year (4/19), and you can learn more about its history and meaning here: https://www.youtube.com/watch?v=InD5_Ml1OxQ #Psychedelics #Psychedelic #Psychedelia #LSD #Psilocybin #Psilocin #Weed #Canabis #Drugs
2 boosts · 8 favs · 0 replies · Jan 1, 2026
#drugs#psychedelics#psychedelia#lsd#psilocybin#psilocin
@[email protected]
Well said my man! #Psychedelics #Psychedelic #Psychedelia #LSD #Psilocybin #Psilocin #Mescaline #DMT #Ayahuasca #MDMA #2CB #Weed #Cannabis #Drugs
2 boosts · 7 favs · 1 replies · Mar 1, 2026
#psychedelics#psychedelic#psychedelia#lsd#psilocybin#psilocin
@[email protected]
@hohokam @HauntedOwlbear Dr. Leary says 'no, like this" #LSD-25 #Mescaline #Psilocybin #Leary #Psychedelic
0 boosts · 1 favs · 1 replies · Apr 3, 2026
#lsd#mescaline#psilocybin#leary#psychedelic
@[email protected]
From @adamscochran on Dead 🐦 1hr ago: From @adamscochran.bsky.social on Dead🐦 1hr ago: To be fair... This is the only hope Trump has for his approval ratings. As one would need heavy doses of psychedelics to think he's doing a good job. ____ Me: #USpol #LSD #Psychedelics #MentalHealth #Health #TurnOnTuneInDropOut With emphasis on the "drop out" Actually, I think it's also, maybe primarily, a desperate attempt by Trump/GOP to claw back the young white male voters they've lost lately.
8 boosts · 1 favs · 1 replies · Apr 18, 2026
#uspol#lsd#psychedelics#mentalhealth#health#turnontuneindropout
@[email protected]
Psychedelics like psilocybin, LSD helps against chronic pain shows a study from the university of Maastricht. ———— We analysed data related to five conditions selected based on diagnostic homogeneity within each of them: fibromyalgia, arthritis, migraine, tension-type headache and sciatica. RESULTS: Except for sciatica, volunteers reported that psychedelics led to better pain relief compared to conventional medication in all examined conditions. More specifically, full doses performed better than conventional medication. https://cris.maastrichtuniversity.nl/en/publications/potential-analgesic-effects-of-psychedelics-on-select-chronic-pai/ #chronicpain #fibromyalgia #arthritis #migraine #headache #sciatica #lsd #psilocybin #psychodelic
1 boosts · 1 favs · 0 replies · Feb 14, 2026
#chronicpain#fibromyalgia#arthritis#migraine#headache#sciatica
@[email protected]
Trump has ordered a fast-track review of psychedelic drugs, including ibogaine, to explore their potential in treating mental health conditions https://english.mathrubhumi.com/news/world/are-psychedelic-drugs-safe-trumps-fast-track-order-raises-questions-wt5tuhu4?utm_source=dlvr.it&utm_medium=mastodon #DonaldTrump #MentalHealth #FDA
1 boosts · 0 favs · 0 replies · Apr 18, 2026
#donaldtrump#mentalhealth#fda
@[email protected]
https://pubmed.ncbi.nlm.nih.gov/41944071/ #psychedelics #psychedelictherapies #ketamine #psychedelicassistedpsychotherapy #ketamineassistedpsychotherapy #mdma #dmt #lsd #ayahausca #psilocybin
0 boosts · 0 favs · 0 replies · Apr 7, 2026
#psychedelics#psychedelictherapies#ketamine#psychedelicassistedpsychotherapy#ketamineassistedpsychotherapy#mdma
@[email protected]
After a Psychedelic session with the right set and setting, my personal website feels more relevant than ever! https://midtsveen.codeberg.page #LSD #Psychedelic #Serotonin5HT2A #Serotonin
0 boosts · 0 favs · 1 replies · Mar 18, 2026
#lsd#psychedelic#serotonin5ht2a#serotonin
@[email protected]
#psychedelics #lsd
1 boosts · 0 favs · 0 replies · Mar 9, 2026
#psychedelics#lsd
@[email protected]
direct, cross‑drug comparison showing that #ketamine drives the brain into the most chaotic (high‑entropy) state of the three #psychedelics tested, aligning with theories that link neural signal diversity to richness of conscious experience. Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, #LSD and #psilocybin (Schartner, , Carhart‑Harris, Barrett, Seth, & Muthukumaraswamy (2017). #consciousness #neuroscience #mentalhealth https://doi.org/10.1038/srep46421
0 boosts · 0 favs · 0 replies · Mar 1, 2026
#consciousness#neuroscience#mentalhealth#ketamine#psychedelics#lsd
@[email protected]
RE: https://social.linux.pizza/@midtsveen/115817239878843124 Legalize LSD, shrooms, and other classic psychedelics. This was never a war on drugs, it’s always been a war on consciousness IMO. #LSD #Shrooms #Psilocybin #Psychedelic #Drugs
0 boosts · 0 favs · 0 replies · Jan 24, 2026
#lsd#shrooms#psilocybin#psychedelic#drugs
@[email protected]
#psychedelics #lsd
0 boosts · 0 favs · 0 replies · Apr 16, 2026
#psychedelics#lsd
@[email protected]
#psychology #psychedelics #lsd #mm120 #anxiety https://www.sciencedaily.com/releases/2025/10/251027023816.htm
0 boosts · 0 favs · 0 replies · Mar 15, 2026
#psychology#psychedelics#lsd#mm120#anxiety
@[email protected]
Psychedelic advice - #TerenceMcKenna https://youtu.be/QsPtpKdS-vE #Psilocybin #LSD
0 boosts · 0 favs · 0 replies · Mar 1, 2026
#terencemckenna#psilocybin#lsd