Neurotrophin-3 produced by motor neurons non-cell autonomously regulates the development of pre-motor interneurons in the developing spinal cord.

Neurotrophin-3 produced by motor neurons non-cell autonomously regulate the development of pre-motor interneurons in the developing spinal cord hypothes.is/a/dsbOvD4zEfGxtXMEgTcITA **eLife Assessment** This is a useful study that seeks to elucidate the molecular mechanisms underlying spinal motor circuit assembly. The authors demonstrate that loss of Onecut transcription factors in spinal motor neurons affects the size and…

Neurotrophin-3 produced by motor neurons non-cell autonomously regulate the development of pre-motor interneurons in the developing spinal cord hypothes.is/a/dpsNcj4zEfGN0j9-dBcYdg **Reviewer #1 (Public review):** Summary: In this study, Angla et al investigate the basis of observations made from previous studies where loss of Onecut (OC) transcription factors leads to changes in spinal interneuron populations that do not…

Neurotrophin-3 produced by motor neurons non-cell autonomously regulate the development of pre-motor interneurons in the developing spinal cord hypothes.is/a/dm4b8D4zEfGxg_Ph0VgO4g **Reviewer #2 (Public review):** The study by Angla et al. proposes a model in which NT-3 produced by motor neurons regulates interneuron numbers and distribution in a non-cell autonomous manner. The authors demonstrate that ablation of motor neurons…

Neurotrophin-3 produced by motor neurons non-cell autonomously regulate the development of pre-motor interneurons in the developing spinal cord hypothes.is/a/dkE7CD4zEfGXNSvZ5_TgNw **Reviewer #3 (Public review):** This manuscript aims to investigate cell extrinsic mechanisms that regulate the differentiation and distribution of interneuron types in the spinal cord. The authors demonstrate that the loss of motor neurons leads to…

Neurotrophin-3 produced by motor neurons non-cell autonomously regulate the development of pre-motor interneurons in the developing spinal cord hypothes.is/a/dg6DID4zEfGa_6s4DOMtrw **Author response:** > **Public Reviews:** > > **Reviewer #1 (Public review):** > > (1) Based on the effects observed with OC vs. Ntf3 cKO, it is unclear whether OC is indeed exerting its non-cell-autonomous effects via Ntf3. Knocking out both Ntf3 and…