Olfactory combinatorial coding in C. elegans supports risk-reward decision making by activating both attractant and repellant olfactory neurons.

Olfactory combinatorial coding supports risk-reward decision making in C. elegans hypothes.is/a/2kcYdD8pEfGP6DvRhVHWog **eLife Assessment** This important study shows that an odorant that is typically thought of as a repellant actually activates both attractant and repellant olfactory neurons in C. elegans. Convincing evidence is provided that nematode worms can…

Olfactory combinatorial coding supports risk-reward decision making in C. elegans hypothes.is/a/2aym6j8pEfGCfpOthMNpHw **Reviewer #3 (Public review):** Summary: This work describes how two chemosensory neurons in C. elegans drive opposite behaviors in response to a volatile cue. Because they have different concentration dependencies, this leads to different…

Olfactory combinatorial coding supports risk-reward decision making in C. elegans hypothes.is/a/2hXLXD8pEfG5mmfhU8Wl_w **Reviewer #1 (Public review):** The authors investigated the response of worms to the odorant 1-octanol (1-oct) using a combination of microfluidics-based behavioral analysis and whole-network calcium imaging. They hypothesized that 1-oct may be…

Olfactory combinatorial coding supports risk-reward decision making in C. elegans hypothes.is/a/2edTsj8pEfGVTm8zrYCgCg **Reviewer #2 (Public review):** Summary: The authors used whole-network imaging to identify sensory neurons that responded to the repellant 1-octanol. While several olfactory neurons responded to the initial onset of odor pulses, two neurons…

Olfactory combinatorial coding supports risk-reward decision making in C. elegans hypothes.is/a/2XX2zD8pEfG2gRdq2YjOTQ **Author response:** The following is the authors’ response to the original reviews. > **Public Reviews:** > > **Reviewer #1 (Public review):** > > …other neurons such as AWB, AWA, and ADL are also involved in the coding process. These neurons likely…