The endoderm cell trajectory in Styela clava reveals a dual developmental origin for the digestive tract.

The endoderm cell trajectory of urochordate Styela clava reveals the dual developmental origin and evolution of digestive tract hypothes.is/a/rM2ewjyLEfGaeU_kCGwV7A **Reviewer #2 (Public review):** This manuscript explores endodermal lineage specification during metamorphosis in Styela clava. As biphasic lifestyle organisms, the endoderm exists as a rudiment in the non-feeding larvae that differentiates…

The endoderm cell trajectory of urochordate Styela clava reveals the dual developmental origin and evolution of digestive tract hypothes.is/a/rTBsADyLEfGSvV-QbX5bag **eLife Assessment** This potentially important paper questions the evolutionary origin of the tunicate endoderm, using single-cell sequencing on a developmental series of the ascidian Styela clava that covers metamorphosis and gut development. The…

The endoderm cell trajectory of urochordate Styela clava reveals the dual developmental origin and evolution of digestive tract hypothes.is/a/hmBfNj1dEfGbeRv2MmEi8Q **Author response:** We sincerely thank the Reviewing Editor, Senior Editor, and both reviewers for their careful and constructive assessment of our manuscript. We are encouraged that the reviewers recognize the value of our dataset and its potential…