The engineered sACE2-Fc fusion protein provides complete prophylactic protection against SARS-CoV-2 through intranasal administration.

Redirection of SARS-CoV-2 to Phagocytes by Intranasal sACE2-Fc as a Universal Decoy Confers Complete Prophylactic Protection hypothes.is/a/wBL-2D2OEfGW6TOd2rdM3Q **Reviewer #3 (Public review):** Strengths: The core strength of this study lies in its innovative demonstration that an engineered sACE2-Fc fusion redirects virus-decoy complexes to Fc-mediated phagocytosis and lysosomal clearance in…

Redirection of SARS-CoV-2 to Phagocytes by Intranasal sACE2-Fc as a Universal Decoy Confers Complete Prophylactic Protection hypothes.is/a/v8qASj2OEfGIN-NpPyj02g **Author response:** The following is the authors’ response to the original reviews. > **Public Reviews:** > > **Reviewer #1 (Public review):** > > Summary: > > This manuscript by Wang et al. describes the development of an optimized soluble ACE2-Fc…

Redirection of SARS-CoV-2 to Phagocytes by Intranasal sACE2-Fc as a Universal Decoy Confers Complete Prophylactic Protection hypothes.is/a/wHnakD2OEfGQY6PqFlPJ7g **Reviewer #1 (Public review):** Summary: This manuscript by Wang et al. describes the development of an optimized soluble ACE2-Fc fusion protein, B5-D3, for intranasal prophylaxis against SARS-CoV-2. As shown, B5-D3 conferred protection not only…