The mitochondrial bc1-complex in mature Toxoplasma gondii bradyzoites is a viable drug target for eliminating persistent tissue cysts.

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites hypothes.is/a/JsfLNjzMEfGX1H9FwTMRIQ **eLife Assessment** This valuable study utilizes a newly developed approach to culture T gondii bradyzoites in myotubes, and then takes advantage of the antiparasitic compound collection known as the Pathogen Box, to find compounds that target both…

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites hypothes.is/a/JioySjzMEfG1XG8nACZWsQ **Reviewer #1 (Public review):** Summary: The authors' goal was to advance the understanding of metabolic flux in the bradyzoite cyst form of the parasite T. gondii, since this is a major form of transmission of this ubiquitous parasite, but very…

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites hypothes.is/a/JboF4jzMEfGZCmcoa4iDCA **Reviewer #3 (Public review):** Summary: The authors described an exciting 400-drug screening using a MMV pathogen box to select compounds that effectively affects the medically important Toxoplasma parasite bradyzoite stage. This work utilises…

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites hypothes.is/a/Je67rDzMEfGgeDdmtdBa6g **Reviewer #2 (Public review):** Summary: A particular challenge in treating infections caused by the parasite Toxoplasma gondii is to target (and ultimately clear) the tissue cysts that persist for the lifetime of an infected individual. The…

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites hypothes.is/a/JYri0DzMEfGcps9HY8vg5w **Author response:** The following is the authors’ response to the previous reviews > **Public Reviews:** > > **Reviewer #1 (Public review):** > > Summary: > > The authors' goal was to advance the understanding of metabolic flux in the bradyzoite cyst…

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites hypothes.is/a/JioySjzMEfG1XG8nACZWsQ **Reviewer #1 (Public review):** Summary: The authors' goal was to advance the understanding of metabolic flux in the bradyzoite cyst form of the parasite T. gondii, since this is a major form of transmission of this ubiquitous parasite, but very…

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites hypothes.is/a/JYri0DzMEfGcps9HY8vg5w **Author response:** The following is the authors’ response to the previous reviews > **Public Reviews:** > > **Reviewer #1 (Public review):** > > Summary: > > The authors' goal was to advance the understanding of metabolic flux in the bradyzoite cyst…

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites hypothes.is/a/Je67rDzMEfGgeDdmtdBa6g **Reviewer #2 (Public review):** Summary: A particular challenge in treating infections caused by the parasite Toxoplasma gondii is to target (and ultimately clear) the tissue cysts that persist for the lifetime of an infected individual. The…

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites hypothes.is/a/JsfLNjzMEfGX1H9FwTMRIQ **eLife Assessment** This valuable study utilizes a newly developed approach to culture T gondii bradyzoites in myotubes, and then takes advantage of the antiparasitic compound collection known as the Pathogen Box, to find compounds that target both…

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites hypothes.is/a/JboF4jzMEfGZCmcoa4iDCA **Reviewer #3 (Public review):** Summary: The authors described an exciting 400-drug screening using a MMV pathogen box to select compounds that effectively affects the medically important Toxoplasma parasite bradyzoite stage. This work utilises…