The study identifies key genetic drivers of human anterior neural tube closure through single-gene perturbations.

Arrayed single-gene perturbations identify drivers of human anterior neural tube closure hypothes.is/a/FvKnqD8pEfGZv_dIsaVZmQ **Reviewer #1 (Public review):** Summary: This is a wonderful and landmark study in the field of human embryo modeling that uses patterned human gastruloids and conducts a functional screen on neural tube closure and identified positive and…

Arrayed single-gene perturbations identify drivers of human anterior neural tube closure hypothes.is/a/FsKrXD8pEfGDUXeTFRDrFg **Author response:** The following is the authors’ response to the original reviews. > **Public Reviews:** > > **Reviewer #1 (Public review):** > > Summary: > > This is a wonderful and landmark study in the field of human embryo modeling. It uses…

Arrayed single-gene perturbations identify drivers of human anterior neural tube closure hypothes.is/a/FyGKvj8pEfGyPqtAkmCpcg **eLife Assessment** This landmark study investigates how patterned human gastruloids can provide insights into neural tube closure. Using a screen, they identified positive and negative regulators and defines the epistasis among them using…