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The study identifies thousands of putative enhancers regulating key genes in cerebellar granule cell progenitors.

GeneticsTechnologyScienceApr 22, 2026score 0.174 posts · 0 replies across 1 instances
This thread discusses a study on the long-range gene regulatory landscape of cerebellar granule neuron progenitors, focusing on the roles of CHD7 and Atoh1 in enhancers and the identification of regulatory interactions through techniques like promoter capture Hi-C. The authors address reviewer comments and revise their manuscript accordingly.

Claims

The study identifies thousands of putative enhancers regulating key genes in cerebellar granule cell progenitors.
Parent: Scientific ResearchEntity: Gene Regulatory StudiesSub-entity: Cerebellar Granule Neuron ProgenitorsImpact: positiveDate: Apr 22, 2026Target: The identification of putative enhancers regulating key genes in cerebellar granule cell progenitors.

Source posts

@[email protected]
The long-range gene regulatory landscape of cerebellar granule neuron progenitors hypothes.is/a/20dBkD5mEfG7mWPN2ntVuw **Reviewer #1 (Public review):** This study by Riegman & George et al. investigates the roles of the chromatin remodeling factor CHD7 and the proneural transcription factor Atoh1 at enhancers in cerebellar granule cells (GCs). Enhancers were…
0 boosts · 0 favs · 0 replies · Apr 22, 2026
@[email protected]
The long-range gene regulatory landscape of cerebellar granule neuron progenitors hypothes.is/a/2xQF5j5mEfGV8AOcMeJmkA **Reviewer #2 (Public review):** Summary: In this manuscript, the authors aim to identify active, long-range regulatory interactions in cerebellar granule cell progenitors (GCps). As such, the authors perform promoter capture Hi-C to map…
0 boosts · 0 favs · 0 replies · Apr 22, 2026
@[email protected]
The long-range gene regulatory landscape of cerebellar granule neuron progenitors hypothes.is/a/2udbrj5mEfGSK5MsHPp4rw **Reviewer #3 (Public review):** Summary: In this work, Riegman et al. establish the promoter interactome of cerebellar granule cell progenitors (CGPs) and identify thousands of putative enhancers regulating key genes in this cell population. The…
0 boosts · 0 favs · 0 replies · Apr 22, 2026
@[email protected]
The long-range gene regulatory landscape of cerebellar granule neuron progenitors hypothes.is/a/2pf7mj5mEfGgVMtF5ec1og **Author response:** > **General Statements** We thank the reviewers for their careful and supportive reviews of our manuscript. We have addresses all the reviewers comments and extensively revised the manuscript accordingly. During our revisions, we…
0 boosts · 0 favs · 0 replies · Apr 22, 2026
@[email protected]
The long-range gene regulatory landscape of cerebellar granule neuron progenitors hypothes.is/a/20dBkD5mEfG7mWPN2ntVuw **Reviewer #1 (Public review):** This study by Riegman & George et al. investigates the roles of the chromatin remodeling factor CHD7 and the proneural transcription factor Atoh1 at enhancers in cerebellar granule cells (GCs). Enhancers were…
0 boosts · 0 favs · 0 replies · Apr 22, 2026
@[email protected]
The long-range gene regulatory landscape of cerebellar granule neuron progenitors hypothes.is/a/2xQF5j5mEfGV8AOcMeJmkA **Reviewer #2 (Public review):** Summary: In this manuscript, the authors aim to identify active, long-range regulatory interactions in cerebellar granule cell progenitors (GCps). As such, the authors perform promoter capture Hi-C to map…
0 boosts · 0 favs · 0 replies · Apr 22, 2026
@[email protected]
The long-range gene regulatory landscape of cerebellar granule neuron progenitors hypothes.is/a/2udbrj5mEfGSK5MsHPp4rw **Reviewer #3 (Public review):** Summary: In this work, Riegman et al. establish the promoter interactome of cerebellar granule cell progenitors (CGPs) and identify thousands of putative enhancers regulating key genes in this cell population. The…
0 boosts · 0 favs · 0 replies · Apr 22, 2026
@[email protected]
The long-range gene regulatory landscape of cerebellar granule neuron progenitors hypothes.is/a/2pf7mj5mEfGgVMtF5ec1og **Author response:** > **General Statements** We thank the reviewers for their careful and supportive reviews of our manuscript. We have addresses all the reviewers comments and extensively revised the manuscript accordingly. During our revisions, we…
0 boosts · 0 favs · 0 replies · Apr 22, 2026