The study suggests that the digestive tract of the urochordate Styela clava has a dual developmental origin, which may provide insights into the evolutionary development of similar structures in other species.

The endoderm cell trajectory of urochordate Styela clava reveals the dual developmental origin and evolution of digestive tract hypothes.is/a/rQAp-jyLEfGLV_OiVIxW7A **Reviewer #1 (Public review):** Summary: The authors employ state-of-the-art single-cell sequencing technologies to map the gene expression profiles of the developing digestive tract in the ascidian Styela clava, a member of the invertebrate…

The endoderm cell trajectory of urochordate Styela clava reveals the dual developmental origin and evolution of digestive tract hypothes.is/a/rTBsADyLEfGSvV-QbX5bag **eLife Assessment** This potentially important paper questions the evolutionary origin of the tunicate endoderm, using single-cell sequencing on a developmental series of the ascidian Styela clava that covers metamorphosis and gut development. The…