The ubiquitin ligase ITCH plays a significant role in regulating the life cycle of SARS-CoV-2 by mediating the ubiquitination of viral envelope and membrane proteins.

Virology Healthcare ScienceApr 23, 2026score 0.173 posts · 0 replies across 1 instances

This thread discusses a study on how the ubiquitin ligase ITCH regulates the life cycle of SARS-CoV-2, focusing on its role in ubiquitinating viral proteins. The study's findings are reviewed and assessed by experts, highlighting its significance in understanding viral mechanisms and potential therapeutic targets.

Claims

Parent: Medical ResearchEntity: ITCHSub-entity: Ubiquitin LigaseImpact: positiveDate: Apr 23, 2026Target: The role of ITCH in regulating SARS-CoV-2 life cycle

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Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

hypothes.is/a/7055-j8qEfGKlMPbG6fVNg

**Author response:**

The following is the authors’ response to the original reviews.

> **Public Reviews:**
> 
> **Reviewer #1 (Public review):**
> 
> Summary:
> 
> The authors investigated the role of an E3 ubiquitin ligase ITCH in regulating the viral…

0 boosts · 0 favs · 0 replies · Apr 23, 2026

@[email protected]

Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

hypothes.is/a/74xXUj8qEfGVUNO9m-psUg

**Reviewer #1 (Public review):**  
  
Summary:  
  
The authors investigated the role of an E3 ubiquitin ligase ITCH in regulating the viral life cycle of SARS-CoV-2. The authors showed that ITCH mediates ubiquitination of the membrane (M) and envelope (E)…

0 boosts · 0 favs · 0 replies · Apr 23, 2026

@[email protected]

Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

hypothes.is/a/770j0j8qEfGAcltU8uH17A

**eLife Assessment**  
  
This valuable study demonstrates that the E3 ligase ITCH regulates several steps of the SARS-CoV-2 replication cycle by enhancing ubiquitination of viral envelope and membrane proteins. The phenotypic data are based on solid…

0 boosts · 0 favs · 0 replies · Apr 23, 2026